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Clinical trials have proven that Viqua™
can increase skin hydration by 40%, reduce wrinkles by 26%, fade dark spots and blemishes, and promote microcirculation.

Research Proven

Viqua™ protects the skin to the deepest layers

Collagen and elastin are large proteins that make up the deep structure of the skin (see figure below). They also affect the overall firmness and elasticity of the skin. Collagenase and elastase are enzymes that hinder the repair and regeneration of these large proteins, leading to wrinkle formation. In vitro tests have shown that Viqua™ is an effective inhibitor of collagenase and elastase at low concentrations, significantly helping to reduce aging symptoms.

Inhibit Elastase Inhibit Collagenase

% Inhibition % Inhibition

100

50 ppm 30 ppm 20 ppm 10 ppm 300 ppm 250 ppm 150 ppm

Protect Microcirculation

After four weeks of Viqua™ treatment, vascular permeability is significantly reduced, and blood circulation is promoted.

Effects in Cells

Viqua™ captures free radicals from within mitochondria

Viqua™ reduces oxidative activity within cells A key in vitro study has shown that Viqua™ can intelligently clear free radicals within the mitochondria of skin cells and restore healthy metabolic mechanisms.

% Oxidation

300

200

-30%

-42%

100

Control Sample 0.1% VIQUA 1% VIQUA

Human skin cells—fat cells—were cultured in a medium containing Viqua™. Viqua™ was stained with fluorescent red to make it visible under a microscope. Electron microscope results (left image) show that Viqua™ successfully entered fat cells and remained in the mitochondria.

Subsequent experiments showed that Viqua™ can be used by fat cell mitochondria to eliminate free radicals.

Clinical Results

A 4-week clinical test was conducted on 30 subjects to evaluate the efficacy of Viqua™ compared to a placebo group. At the beginning of the test, half of the subjects chose to use Viqua™ capsules, while the other half used placebo tablets – neither group knew which they were taking.

By the end of the test, results scientifically proved that the skin of subjects taking Viqua™ showed significant improvement:

Hydration

Skin Smoothness

Anti-inflammatory
Effects

Whitening

Skin moisture content significantly increased (+40%), while the placebo group saw a decrease (-0.3%).
The upper skin layer moisture content in the Viqua® group significantly increased (+51%).
Skin smoothness improved (+27%), and the depth of fine lines and wrinkles was significantly reduced (decrease: -26%).
Vascular reconstruction indicated effective inhibition of inflammatory processes.
Overall skin tone brightened, and dark spots/blemishes were reduced.

The self-assessment results of the subjects were consistent with the above findings. The study results for Viqua® were also far higher than those of the placebo group.

Scientific References

Pomegranate: The Most Powerful Anti-aging Weapon Calling pomegranate a "superfruit" is not just marketing; extensive clinical research supports this claim:

Antioxidant Capacity of Pomegranate Extracts Cardiovascular Disease Prevention Anti-cancer

Pomegranate ingredients which mimic the Polyphenol ratio of the fruit; potent synergistic effects have been observed in ’natural spectrum’ extracts—particularly pomegranate concentrate normalized to Punicalagins.
J Nutr Biochemistry 2005 (16) 360—367.

Intervention of anti–oxidant system function of aged rats by giving fruit juices with different anti-oxidant capacities. Xu J, Guo CJ, Yang JJ, Wei JY, Li YF, Pang W, Jiang YG, Cheng S. Dept of Nutrition, Institute of Hygiene & Environmental Medicine, Acedemy of Military Medical Sciences, Tianjin, China.

Determination of Phenolic compounds in pomegranate juice by HPLC.
Artik N, Ceremroglu B, Murakami H, Mori T. Fruit Process. 1998;8:492–499.

Antimicrobial Effects

Punica granatum (Pomegranate) juice provides an HIV-1 entry inhibitor and candidate topical microbicide.
Neurath AR. et al. BMC Infect Dis. 2004 Oct 14;4:41.

Neuroprotective Effects

Maternal dietary supplementation with pomegranate juice is neuroprotective in an animal model of neonatal hypoxic-ischemic brain injury.
Loren DJ. et al. Pediatr. Res. 2005 Jun;57(6):858-64. Epub 2005 Mar.

Neuroprotective Effects

Inhibitory effect of an Ellagic Acid-rich pomegranate extract on Tyrosinase activity and ultraviolet-induced pigmentation.
Yoshimura M, Watanabe Y, Kasai K, Yamakoshi J, Koga T. Research and Development Division, Kikkoman Corporation.

Pomegranate juice consumption reduces oxidative stress, atherogenic modifications to LDL and platelet aggregation: studies in humans and in atherosclerotic Apolipoprotein E–deficient mice.
Aviram M, Dronfeld L, Rosenblat M, et al. Am J Clin Nutr. 2000;71:1062—1076.

Pomegranate juice flavonoids inhibit low–density lipoprotein oxidation and cardiovascular disease: studies in atherosclerotic mice and in humans.
Aviram M, Dornefeld L, Kaplan M, Gaitini D, Nitecki S, Hofman A, Rosenblat M, Volkova N, Presser D, Attias J, Hayek T, Fuhrman B. Lipid Research Laboratory, Technion Faculty of Medicine, Israel.

Wound Healing

Study on wound healing activity of Punica granatum peel.
Murphy KN. et al., J Med Food. 2004 Summer;7(2):256-9.

Wound Healing

Oxidative stress in arteriogenic erectile dysfunction: prophylactic role of antioxidants. Azadzoi KM. et al. J Urol. 2005 Jul;174(1):386-93.

Anti-aging Effects on Skin

Pomegranate as a cosmeceutical source: pomegranate fractions promote proliferation and procollagen synthesis and inhibit matrix metalloproteinase-1 production in human skin cells.
Journal of Ethnopharmacology 103: 311-318, 2006.

Safety

Repeated oral administration of high doses of the pomegranate ellagitannin punicalagin to rats for 37 days is not toxic.
Cerda B. et al. J Agric Food Chem. 2003 May 21;51(11):3493-501.

Differentiation-promoting activity of pomegranate (punica granatum) fruit extracts in HL-60 human promyelocytic leukemia cells.
Apr 2004, Vol. 7, No. 1: 13-18.

Chemopreventive and adjuvant therapeutic potential of pomegranate (punica granatum) for human breast cancer.
Kim ND, et al. Breast Cancer Res Treat 2002; 71:203-17.

Anthocyanin- and hydrolysable tannin-rich pomegranate fruit extract modulates MAPK and NF-kappaB pathways and inhibits skin tumorigenesis in CD-1 mice.
Afaq F. et al. Int J Cancer 2005 Jan 20;113(3)

Bioavailability

Punica granatum (Pomegranate) juice provides an HIV-1 entry inhibitor and candidate topical microbicide.
Neurath AR. et al. BMC Infect Dis. 2004 Oct 14;4:41.

In vitro gastrointestinal digestion study of pomegranate juice phenolic compounds, anthocyanins, and vitamin C.
Perez-Vicente A. et al., J Agric Food Chem. 2002 Apr 10;50(8):2308-12

Anti-ulcer Effects

The inhibition of gastric mucosal injury by Punica granatum L. (pomegranate) methanolic extract.
Ajaikumar KB. Et al. J Ethnopharmacol. 2005 Jan 4;96(1-2):171-6.